3,4-METHYLENEDIOXYPHENOL FOR SYNTHESIS
Sesamol
CAS: 533-31-3
Molecular Formula: C7H6O3
3,4-METHYLENEDIOXYPHENOL FOR SYNTHESIS - Names and Identifiers
| Name | Sesamol |
| Synonyms | Sesamol NSC 59256 1,3-Benzodioxol-5-ol 3,4-Methylenedioxyphenol 1,3-Benzodioxol-5-ol, 9CI 3,4-(Methylenedioxy)phenol 3,4-(methylenedioxy)-pheno (3,4-Methylenedioxyphenol) 5-Hydroxy-1,3-benzodioxole 3,4-(Methylenedioxy) phenol 1,2,4-Benzenetriol Methylene ether Methylene ether of oxyhydroquinone 4-Hydroxy-1,2-Methylenedioxybenzene 3,4-METHYLENEDIOXYPHENOL FOR SYNTHESIS 5-Hydroxy-1,3-benzodioxole3,4-Methylenedioxyphenol |
| CAS | 533-31-3 |
| EINECS | 208-561-5 |
| InChI | InChI=1/C7H6O3/c8-5-1-2-6-7(3-5)10-4-9-6/h1-3,8H,4H2 |
| InChIKey | LUSZGTFNYDARNI-UHFFFAOYSA-N |
3,4-METHYLENEDIOXYPHENOL FOR SYNTHESIS - Physico-chemical Properties
| Molecular Formula | C7H6O3 |
| Molar Mass | 138.12 |
| Density | 1.2112 (rough estimate) |
| Melting Point | 62-65 °C (lit.) |
| Boling Point | 113-116°C 2mm |
| Flash Point | 113-116°C/2mm |
| Water Solubility | slightly soluble |
| Solubility | DMSO : ≥ 100 mg/mL (724.01 mM);Ethanol : ≥ 100 mg/mL (724.01 mM) |
| Appearance | White to off-white (Solid) |
| Color | off-white to tan |
| BRN | 127405 |
| pKa | 10.08±0.20(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Sensitive | Light Sensitive |
| Refractive Index | 1.4850 (estimate) |
| MDL | MFCD00005827 |
| Physical and Chemical Properties | Gray-brown needle-like crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from sesame oil. |
| Use | Used as antioxidant, pharmaceutical intermediates and cosmetic additives |
3,4-METHYLENEDIOXYPHENOL FOR SYNTHESIS - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | SM0890000 |
| TSCA | Yes |
| HS Code | 29329970 |
| Hazard Note | Irritant |
3,4-METHYLENEDIOXYPHENOL FOR SYNTHESIS - Upstream Downstream Industry
| Raw Materials | Sulfuric acid |
3,4-METHYLENEDIOXYPHENOL FOR SYNTHESIS - Reference
| Reference Show more | 1. Wang Nan Nan, Li Xiaodong, Wang Xue de. Enhancement of oxidative stability of cold-pressed sesame oil catalyzed by phospho-tungstic Heteropoly acid and sesamin [J]. China Oils and fats, 2018, v.43;No.327(05):79-83. 2. Chen, Yazhen, et al. "Effect of oncology and in vitro fusion on phenic profiles and antioxant activity of water-soluble extracts from sesame." Food and Chemical Biology 139 (2020): 111239.https://doi.org/10.1016/j.fct.2020.111239 3. [IF = 6.023] Yazhen Chen et al."Effects of thermal preparation and in vitro digestion on lignan profiles and antioxidant activity in defatted-sesame meal."Food Chem Toxicol. 2019 Jun;128:89 4. [IF=6.023] Yazhen Chen et al."Effect of roasting and in vitro digestion on phenolic profiles and antioxidant activity of water-soluble extracts from sesame."Food Chem Toxicol. 2020 May;139:111239 5. [IF=5.396] Yang Yang et al."Sesamol supplementation alleviates nonalcoholic steatohepatitis and atherosclerosis in high-fat, high carbohydrate and high-cholesterol diet-fed rats."Food Funct. 2021 Oct;12(19):9347-9359 |
3,4-METHYLENEDIOXYPHENOL FOR SYNTHESIS - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| sesame oil is an important component | sesame phenol, also known as 3, 4-methylenedioxyphenol, fat-soluble lignans, is an important component of sesame oil and an important quality stabilizer of sesame oil. Sesame phenol exists in sesame seeds, sesame oil and sesame meal, and can be produced by continuous decomposition of sesame linins and the like during thermal processing, up to 64.4 mg/(100g) in sesame oil. sesamol has very strong antioxidant capacity and has been proved to have anti-inflammatory and regulating intestinal function. Antioxidants commonly used in food and medicine. At the same time, it is an important starting material for the synthesis of antihypertensive drugs and cardiovascular drugs. It is also a raw material for the pesticide piperyl butyl ether. Sesamin is very tight in the world, especially in the field of drug synthesis. |
| application | sesame phenol naturally exists in sesame oil with very little content. This product is an aromatic phenolic compound, which can interact with acids, aldehydes, alcohols (phenols) and other compounds to form esters and ether derivatives. It is widely used in the preparation of a series of fine chemicals such as anti-mold antibacterial agents, anti-cancer, anti-hypertensive drugs, high-grade hair conditioning agents for shampoo, etc. It is an expensive chemical and pharmaceutical intermediate raw material with good development and utilization value and application prospects. It is also an important intermediate for the synthesis of anticancer drugs and pesticide synergists, and also as an intermediate for antihypertensive and cerebrovascular disease drugs. |
| synthesis method | there are three main synthesis techniques for sesamol: one is extracted from sesame oil, the other is fully synthesized from pepper amine, and the third is a semi-synthetic route from jasmine. The extraction of sesamol from sesame oil has a large solvent consumption and high cost, which is not suitable for industrial production; the total synthesis route starting from piperzine requires diazotization and hydrolysis to obtain a low yield of sesamol. At the same time, due to the diazotization and hydrolysis process, it is inevitable that there will be a coupling side reaction to produce pigment material inclusions. It is difficult to remove in the product, so the color of sesamol is not good, and the application is limited; the semi-synthetic route starting from jasmonal, it is the most industrialized process route, and the product quality and color are very good. Sesame phenol was synthesized from jasmine aldehyde, mainly through two steps of oxidation and hydrolysis. In this project technology, low-cost oxidant and reaction extraction technology are used, so that the generated products quickly leave the reaction zone, greatly reducing the occurrence of side reactions. The yield can reach more than 60%, the product content is 98%, and it is white crystal. |
| The metabolic pathway of sesamol in the human body | After being ingested, sesamol is absorbed into the body through the gastrointestinal tract. First, part of sesamol is metabolized by two-phase enzymes in the liver. Conjugated products such as sesamol sulfate and sesamol glucuronide, and then the remaining sesamol and its conjugated products are transported to other tissues such as the brain and lungs, it is mainly distributed in the lungs and kidneys and eventually excreted in urine and feces. |
| Uses | Sesame phenol is an important aroma component of sesame oil and an important quality stabilizer of sesame oil; it is widely used in the preparation of anti-mold and antibacterial agents, anti-cancer, Anti-hypertensive drugs, high-grade hair conditioning agents for shampoo, etc.; it is an expensive chemical and pharmaceutical intermediate raw material with good development and utilization value and application prospects; it is an important intermediate for the synthesis of anticancer drugs and pesticide synergists, and also as an intermediate for antihypertensive and cerebrovascular disease drugs; it is used as food and medicine Sesame phenol naturally exists in sesame oil with very little content. This product is an aromatic phenolic compound, which can interact with acids, aldehydes, alcohols (phenols) and other compounds to form esters and ether derivatives. It is widely used in the preparation of a series of fine chemicals such as anti-mold antibacterial agents, anti-cancer, anti-hypertensive drugs, high-grade hair conditioning agents for shampoo, etc. It is an expensive chemical and pharmaceutical intermediate raw material with good development and utilization value and application prospects. It is also an important intermediate for the synthesis of anticancer drugs and pesticide synergists, and also as an intermediate for antihypertensive and cerebrovascular disease drugs. use as antioxidants, pharmaceutical intermediates and cosmetic additives sealed, cool, dry and dark storage |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
Supplier List
Featured ProductsSpot supply
Product Name: Sesamol Request for quotationCAS: 533-31-3
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217
Wechat: 18627766980
Spot supply
Product Name: Sesamol Request for quotationCAS: 533-31-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Sesamol Request for quotationCAS: 533-31-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Sesamol Request for quotation
CAS: 533-31-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 533-31-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Paroxetine Impurity 20（Paroxetine HCl Anhydrous EP Impurity B） Visit Supplier Webpage Request for quotationCAS: 533-31-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Sesamol Request for quotationCAS: 533-31-3
Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276
Wechat: A2020071098
Product Name: Sesamol Request for quotation
CAS: 533-31-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 533-31-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Sesamol Visit Supplier Webpage Request for quotationCAS: 533-31-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Featured ProductsSpot supply
Product Name: Sesamol Request for quotationCAS: 533-31-3
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217
Wechat: 18627766980
Spot supply
Product Name: Sesamol Request for quotationCAS: 533-31-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Sesamol Request for quotationCAS: 533-31-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Sesamol Request for quotation
CAS: 533-31-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 533-31-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Paroxetine Impurity 20（Paroxetine HCl Anhydrous EP Impurity B） Visit Supplier Webpage Request for quotationCAS: 533-31-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Sesamol Request for quotationCAS: 533-31-3
Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276
Wechat: A2020071098
Product Name: Sesamol Request for quotation
CAS: 533-31-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 533-31-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Sesamol Visit Supplier Webpage Request for quotationCAS: 533-31-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for 3,4-METHYLENEDIOXYPHENOL FOR SYNTHESIS